Dichloromethane → (7-Bromo-1,2,3,4-tetrahydro-naphthalen-2-yl)-piperidin-4-yl-propyl-amine

Reaction equation

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([N:14]([CH2:15][CH2:16][CH3:17])[CH:18]2[CH2:19][c:20]3[cH:21][c:22]([Br:28])[cH:23][cH:24][c:25]3[CH2:26][CH2:27]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH2:36]([Cl:37])[Cl:38].[OH:29][C:30]([C:31]([F:32])([F:33])[F:34])=[O:35]>>[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]([CH2:15][CH2:16][CH3:17])[CH:18]2[CH2:19][c:20]3[cH:21][c:22]([Br:28])[cH:23][cH:24][c:25]3[CH2:26][CH2:27]2)[CH2:12][CH2:13]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 11362947HCID 11362947, compound

Product 1

HCID 22649540(7-Bromo-1,2,3,4-tetrahydro-naphthalen-2-yl)-piperidin-4-yl-propyl-amine

Sources & evidence

ORD record: ord-59a82619e0c347a99c16ac3a3797f4bf
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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