Ammonium Hydroxide → HCID 178461168, compound
Reaction equation
S[C:2]1[N:3]=[C:4]([OH:12])[C:5]2[C@H:10]([CH3:11])[CH2:9][CH2:8][C:6]=2[N:7]=1.[NH4+].[OH-]>O.[Ni]>[CH3:11][C@H:10]1[C:5]2[C:4]([OH:12])=[N:3][CH:2]=[N:7][C:6]=2[CH2:8][CH2:9]1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
To a suspension of (R)-2-mercapto-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-ol (12 g, 65.8 mmol) in distilled water (100 mL) was added Raney Nickel (15 g) and NH4OH (20 mL). The mixture was refluxed for 3 hours then filtered, and the filtrate was concentrated to afford (R)-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-ol (9.89 g, 99%). MS (APCI+) [M+H]+151.
Workup
- temperatureThe mixture was refluxed for 3 hours
- filtrationthen filtered
- concentrationthe filtrate was concentrated
Sources & evidence
- ORD record
- ord-9309701971a04d7a82d31fa78b347bd8
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08846681B2
Reaction notes
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