Potassium Cation → 2-[(4-Ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl-4-fluoropyrrolidine-2-carbonitrile

HRID 823538

Reaction equation

HRID 823538 reaction equation
[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7].[F:22][CH:23]1[CH2:24][CH:25]([C:41]#[N:42])[N:26]([C:28]([CH2:29][O:30][S:31]([c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)(=[O:38])=[O:39])=[O:40])[CH2:27]1.[I-:44].[K+:43].[NH2:8][C:9]12[CH2:10][CH2:11][C:12]([C:17](=[O:18])[O:19][CH2:20][CH3:21])([CH2:13][CH2:14]1)[CH2:15][CH2:16]2>>[NH:8]([C:9]12[CH2:10][CH2:11][C:12]([C:17](=[O:18])[O:19][CH2:20][CH3:21])([CH2:13][CH2:14]1)[CH2:15][CH2:16]2)[CH2:29][C:28]([N:26]1[CH:25]([C:41]#[N:42])[CH2:24][CH:23]([F:22])[CH2:27]1)=[O:40]

Participants

6

Reactant 5

HCID 813Potassium CationHCID 6422Trifluoroacetic acidHCID 30165Iodide IonHCID 23149693Ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylateHCID 150304301[2-(2-Cyano-4-fluoropyrrolidin-1-yl)-2-oxoethyl] benzenesulfonate

Product 1

HCID 231496942-[(4-Ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl-4-fluoropyrrolidine-2-carbonitrile

Sources & evidence

ORD record
ord-41a11d6edc9b4033a0aa601294008826
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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