1,4-Dioxane → (5-Bromo-pyrimidin-2-yl)-(2-fluoro-5-trifluoromethyl-benzyl)-amine

HRID 823990

Reaction equation

HRID 823990 reaction equation
[Br:23][c:24]1[cH:25][n:26][c:27]([Cl:30])[n:28][cH:29]1.[CH2:31]1[O:32][CH2:33][CH2:34][O:35][CH2:36]1.[CH:14]([N:15]([CH2:16][CH3:17])[CH:18]([CH3:19])[CH3:20])([CH3:21])[CH3:22].[F:1][c:2]1[c:3]([CH2:4][NH2:5])[cH:6][c:7]([C:10]([F:11])([F:12])[F:13])[cH:8][cH:9]1>>[F:1][c:2]1[c:3]([CH2:4][NH:5][c:27]2[n:26][cH:25][c:24]([Br:23])[cH:29][n:28]2)[cH:6][c:7]([C:10]([F:11])([F:12])[F:13])[cH:8][cH:9]1

Participants

5

Reactant 4

HCID 312751,4-DioxaneHCID 81531DiisopropylethylamineHCID 5338392-Fluoro-5-(trifluoromethyl)benzylamineHCID 6066655-Bromo-2-chloropyrimidine

Product 1

HCID 67087263(5-Bromo-pyrimidin-2-yl)-(2-fluoro-5-trifluoromethyl-benzyl)-amine

Sources & evidence

ORD record
ord-8e2b7f8f1a92400b8e07d6b48340d75d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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