Dichloromethane → 8-(4-Fluoro-phenyl)-4-[2-(4-methyl-imidazol-1-yl)-thiazol-4-yl]-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Reaction equation

[C:1]([O:2][C:3](=[O:4])[NH:7][c:8]1[c:9]([NH:21][C:22]([CH2:23][C:24](=[O:5])[c:26]2[n:27][c:28](-[n:31]3[cH:32][n:33][c:34]([CH3:36])[cH:35]3)[s:29][cH:30]2)=[O:37])[cH:10][c:11](-[c:14]2[cH:15][cH:16][c:17]([F:20])[cH:18][cH:19]2)[cH:12][cH:13]1)([CH3:6])([CH3:25])[CH3:38].[Cl:46][CH2:47][Cl:48].[F:39][C:40]([F:41])([F:42])[C:43]([OH:44])=[O:45]>>[N:7]1=[C:24]([c:26]2[n:27][c:28](-[n:31]3[cH:32][n:33][c:34]([CH3:36])[cH:35]3)[s:29][cH:30]2)[CH2:23][C:22](=[O:37])[NH:21][c:9]2[c:8]1[cH:13][cH:12][c:11](-[c:14]1[cH:15][cH:16][c:17]([F:20])[cH:18][cH:19]1)[cH:10]2