3,4-Diaminopyridine → HCID 178527813, compound

HRID 82614

Reaction equation

HRID 82614 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([NH2:7])=[C:3]([NH2:8])[CH:2]=1.[C:9](=S)=[S:10].[Cl-].[Cl-].[Ca+2]>CCO>[NH:7]1[C:4]2[CH:5]=[CH:6][N:1]=[CH:2][C:3]=2[N:8]=[C:9]1[SH:10]

Participants

5

Reactant 3

HCID 59183,4-DiaminopyridineHCID 6348Carbon DisulfideHCID 5284359Calcium Chloride

Product 1

HCID 178527813HCID 178527813, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of pyridine-3,4-diamine (5 g) in EtOH (80 mL) was added carbon disulfide (10 mL) at room temperature. The mixture was stirred at 40° C. under a dry atmosphere (CaCl2 tube) for 10 h. The mixture was cooled to room temperature. The resulting white solid was collected by filtration and washed with ether to give 1H-imidazo[4,5-c]pyridine-2-thiol (6.1 g) as a white solid.

Workup

  1. filtrationThe resulting white solid was collected by filtration
  2. washwashed with ether

Sources & evidence

ORD record
ord-88ede3cd1b83468fa729786abb80d652
Source dataset
uspto-grants-2014_09
Patent number
US08846713B2

Linked notes

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