Tributylphosphine → {6-[2-ethyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester

HRID 833257

Reaction equation

HRID 833257 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([CH2:7][n:8]1[cH:9][cH:10][c:11]2[cH:12][cH:13][c:14]([OH:17])[cH:15][c:16]12)=[O:18].[CH2:19]([CH3:20])[n:21]1[n:22][c:23](-[c:28]2[cH:29][cH:30][c:31]([C:34]([F:35])([F:36])[F:37])[cH:32][cH:33]2)[cH:24][c:25]1[CH2:26][OH:27].[CH2:38]([P:39]([CH2:40][CH2:41][CH2:42][CH3:43])[CH2:44][CH2:45][CH2:46][CH3:47])[CH2:48][CH2:49][CH3:50]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([CH2:7][n:8]1[cH:9][cH:10][c:11]2[cH:12][cH:13][c:14]([O:17][CH2:26][c:25]3[n:21]([CH2:19][CH3:20])[n:22][c:23](-[c:28]4[cH:29][cH:30][c:31]([C:34]([F:35])([F:36])[F:37])[cH:32][cH:33]4)[cH:24]3)[cH:15][c:16]12)=[O:18]

Participants

4

Reactant 3

HCID 13831TributylphosphineHCID 69280245[2-ethyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-methanolHCID 69283069tert-Butyl (6-hydroxy-1H-indol-1-yl)acetate

Product 1

HCID 69284503{6-[2-ethyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester

Sources & evidence

ORD record
ord-2471e08d0d1d41ea820ca81c83e4f313
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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