Hydroxide → 2-Fluoro-3-(tetrahydrofuran-3-YL)pyridine

Reaction equation

[CH2:13]1[O:14][CH2:15][CH2:16][CH2:17]1.[O:1]1[CH2:2][CH:3]([c:6]2[c:7]([F:12])[n:8][cH:9][cH:10][cH:11]2)[CH:4]=[CH:5]1.[OH-:18].[OH-:20].[Pd+2:19]>>[O:1]1[CH2:2][CH:3]([c:6]2[c:7]([F:12])[n:8][cH:9][cH:10][cH:11]2)[CH2:4][CH2:5]1

Participants

Reactant 4

HCID 961Hydroxide2×

HCID 8028Tetrahydrofuran

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 59327230HCID 59327230, compound

Product 1

HCID 593272332-Fluoro-3-(tetrahydrofuran-3-YL)pyridine

Sources & evidence

ORD record: ord-f9ae46cf81b34dc79dded56c5db66865
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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