Ethanol → 4-oxo-4-(1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)-N-(3-(trifluoromethyl)benzyl)butyric acid amide

HRID 837441

Reaction equation

HRID 837441 reaction equation
[CH3:39][CH2:40][OH:41].[Cl:36][CH2:37][Cl:38].[Cl:42][CH2:43][Cl:44].[O:17]=[C:18]([CH2:19][CH2:20][C:21](=[O:22])[OH:23])[NH:24][CH2:25][c:26]1[cH:27][c:28]([C:32]([F:33])([F:34])[F:35])[cH:29][cH:30][cH:31]1.[O:45]=[CH:46][N:47]([CH3:48])[CH3:49].[c:1]1([CH:7]2[NH:8][CH2:9][CH2:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]32)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([CH:7]2[N:8]([C:21]([CH2:20][CH2:19][C:18](=[O:17])[NH:24][CH2:25][c:26]3[cH:27][c:28]([C:32]([F:33])([F:34])[F:35])[cH:29][cH:30][cH:31]3)=[O:22])[CH2:9][CH2:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]32)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

6

Reactant 5

HCID 702EthanolHCID 6228DimethylformamideHCID 6344Dichloromethane2×HCID 1001371,2,3,4-Tetrahydro-1-phenylisoquinolineHCID 433971044-Oxo-4-(3-(trifluoromethyl)benzylamino)butyric acid

Product 1

HCID 462139164-oxo-4-(1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)-N-(3-(trifluoromethyl)benzyl)butyric acid amide

Sources & evidence

ORD record
ord-cb549c927e394201bf1e3c82f4619f8e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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