Trifluoroacetic acid → HCID 178514772, compound

HRID 839011Notes

Reaction equation

HRID 839011 reaction equation
C1(=O)N(CS(Cl)(=O)=O)C(=O)C2=CC=CC=C12.C1(=O)N(CCS(Cl)(=O)=O)C(=O)C2=CC=CC=C12.C(NS(CN1C(=O)C2=CC=CC=C2C1=O)(=O)=O)(C)(C)C.C(NS(N1C(SC)=NN=N1)(=O)=O)(C)(C)C.C([NH:73][S:74]([CH2:77][N:78]1[C:82]([SH:83])=[N:81][N:80]=[N:79]1)(=[O:76])=[O:75])(C)(C)C.FC(F)(F)C(O)=O>>[S:74]([CH2:77][N:78]1[C:82]([SH:83])=[N:81][N:80]=[N:79]1)(=[O:76])(=[O:75])[NH2:73]

Participants

7

Reactant 6

HCID 6422Trifluoroacetic acidHCID 3087392-Phthalimidoethanesulfonyl chlorideHCID 21315191(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methanesulfonyl chlorideHCID 54174780N-t-butylphthalimidomethanesulfonamideHCID 706001281-N-t-butylsulfamoyl methyltetrazole-5-thiolHCID 178449998HCID 178449998, compound

Product 1

HCID 178514772HCID 178514772, compound

Procedure

When phthalimidomethanesulfonyl chloride is substituted in the procedure of Example 3 for 2-phthalimidoethanesulfonyl chloride, N-t-butylphthalimidomethanesulfonamide is prepared which is converted to 1-N-t-butylsulfamoyl methyltetrazole-5-thiol as described therein. Treatment of 1-N-t-butylsulfamoylmethyltetrazole-5-thiol with trifluoroacetic acid as described in Example 3 gives 1-sulfamoylmethyltetrazole-5-thiol.

Workup

  1. customis prepared which

Sources & evidence

ORD record
ord-ecd99de5dd7c4f36aedd17d3fceb078b
Source dataset
uspto-grants-1978_06
Patent number
US04093723

Reaction notes

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