3-Nitrophenylethyl alcohol → 2-(3-Nitrophenyl)acetaldehyde
Reaction equation
I(C1C=CC=CC=1C(O)=O)(=O)=O.[N+:13]([C:16]1[CH:17]=[C:18]([CH2:22][CH2:23][OH:24])[CH:19]=[CH:20][CH:21]=1)([O-:15])=[O:14]>O1CCCC1>[N+:13]([C:16]1[CH:17]=[C:18]([CH2:22][CH:23]=[O:24])[CH:19]=[CH:20][CH:21]=1)([O-:15])=[O:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
90 mmol of iodoxybenzoic acid are added to 60 mmol of 2-(3-nitrophenyl)ethanol in 300 ml of tetrahydrofuran. The reaction mixture is heated at reflux for 4 hours, then cooled and filtered. The filtrate is concentrated to yield the expected compound.
Workup
- temperatureThe reaction mixture is heated
- temperatureat reflux for 4 hours
- temperaturecooled
- filtrationfiltered
- concentrationThe filtrate is concentrated
Sources & evidence
- ORD record
- ord-29996943fc1d4a4c8cf8dce056347f41
- Source dataset
- uspto-grants-2002_04
- Patent number
- US06365605B1
Reaction notes
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