Ethanesulfonic acid → (s)-7-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-amino]-quinoline-3-carboxylic acid (1-pyridin-2-yl-propyl)-amide ethanesulfonate

HRID 841798

Reaction equation

HRID 841798 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C@@H:7]([NH:10][C:11]([C:13]1[CH:14]=[N:15][C:16]2[C:21]([CH:22]=1)=[CH:20][CH:19]=[C:18]([NH:23][C:24]([C:26]1[C:27]([C:32]3[CH:37]=[CH:36][C:35]([C:38]([F:41])([F:40])[F:39])=[CH:34][CH:33]=3)=[CH:28][CH:29]=[CH:30][CH:31]=1)=[O:25])[CH:17]=2)=[O:12])[CH2:8][CH3:9].[CH2:42]([S:44]([OH:47])(=[O:46])=[O:45])[CH3:43]>C(OCC)(=O)C>[CH2:42]([S:44]([OH:47])(=[O:46])=[O:45])[CH3:43].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C@@H:7]([NH:10][C:11]([C:13]1[CH:14]=[N:15][C:16]2[C:21]([CH:22]=1)=[CH:20][CH:19]=[C:18]([NH:23][C:24]([C:26]1[C:27]([C:32]3[CH:33]=[CH:34][C:35]([C:38]([F:41])([F:39])[F:40])=[CH:36][CH:37]=3)=[CH:28][CH:29]=[CH:30][CH:31]=1)=[O:25])[CH:17]=2)=[O:12])[CH2:8][CH3:9]

Participants

4

Reactant 2

HCID 11668Ethanesulfonic acidHCID 10280962(s)-7-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-amino]-quinoline-3-carboxylic acid (1-pyridin-2-yl-propyl)-amide

Product 1

HCID 131723182(s)-7-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-amino]-quinoline-3-carboxylic acid (1-pyridin-2-yl-propyl)-amide ethanesulfonateYield 102%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

(S)-7-[(4′-Trifluoromethyl-biphenyl-2-carbonyl)-amino]-quinoline-3-carboxylic acid (1-pyridin-2-yl-propyl)-amide (67 mg) was dissolved in 5 ml of ethyl acetate, and ethanesulfonic acid (13 mg, 1 equivalent) was added as a solution in 1.5 ml of ethyl acetate. After 60 min, the mixture was concentrated under vacuum to afford 80 mg of the title compound as a yellow solid.

Workup

  1. concentrationthe mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-53f1f534825345d697313258dd45e509
Source dataset
uspto-grants-2002_04
Patent number
US06369075B1

Linked notes

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