Ethinylestradiol → Norgestimate and Ethinyl Estradiol

HRID 841850

Reaction equation

HRID 841850 reaction equation
[CH3:1][C@@:2]12[C@:18]([OH:21])([C:19]#[CH:20])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:22])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2.[CH3:23][CH2:24][C@@:25]12[C@:33]([O:36][C:37]([CH3:39])=[O:38])([C:34]#[CH:35])[CH2:32][CH2:31][C@H:30]1[C@@H:29]1[CH2:40][CH2:41][C:42]3[C@@H:49]([C@H:28]1[CH2:27][CH2:26]2)[CH2:48][CH2:47]/[C:44](=[N:45]\[OH:46])/[CH:43]=3>>[CH3:23][CH2:24][C@@:25]12[C@:33]([O:36][C:37]([CH3:39])=[O:38])([C:34]#[CH:35])[CH2:32][CH2:31][C@H:30]1[C@@H:29]1[CH2:40][CH2:41][C:42]3[C@@H:49]([C@H:28]1[CH2:27][CH2:26]2)[CH2:48][CH2:47]/[C:44](=[N:45]\[OH:46])/[CH:43]=3.[CH3:1][C@@:2]12[C@:18]([OH:21])([C:19]#[CH:20])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:22])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2

Participants

3

Reactant 2

HCID 5991Ethinylestradiol2×HCID 6540478Norgestimate3×

Product 1

HCID 9571023Norgestimate and Ethinyl Estradiol

Procedure

PEG 8000 is micronized by Jet mill together with ethinyl estradiol at the ratio of ethinyl estradiol to PEG from 1:1 to 1:60. Adjust Jet mill to produce particle size of 5-10 μm. Norgestimate is micronized separately to particle size of 5-15 μm. Micronized norgestimate powder is electrically charged, and deposited on the substrate surface. Micronized PEG 8000/ethinyl estradiol mixture is triboelectrically charged, and deposited on top of norgestimate.

Workup

  1. customAdjust Jet mill to produce particle size of 5-10 μm

Sources & evidence

ORD record
ord-e1ccff6b9e654b2d9c440793599b1e6d
Source dataset
uspto-grants-2002_04
Patent number
US06372246B1

Linked notes

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