Sodium ethoxide → ethyl 2-chloro-5-[3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate

HRID 845903

Reaction equation

HRID 845903 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([NH:16][CH:17]=[CH:18][C:19]([O:21]CC)=O)=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].CC[O-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([N:13]2[C:19](=[O:21])[CH:18]=[CH:17][NH:16][C:14]2=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 54346642Ethyl 2-chloro-5-{3-[2-(ethoxycarbonyl)vinyl]ureido}-benzoate

Product 1

HCID 20130681ethyl 2-chloro-5-[3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

using ethyl 2-chloro-5-{3-[2-(ethoxycarbonyl)vinyl]ureido}-benzoate with sodium ethylate in ethanol there is obtained ethyl 2-chloro-5-[3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate, m.p. 170°-172° C.,

Sources & evidence

ORD record
ord-eb2c795f867c4c87abd8d2afa214f969
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Linked notes

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