Sodium Carbonate → Phthalimide
Reaction equation
FC(F)(F)C1N=C(N2CCNCC2)C=CC=1.BrCC[N:20]1[C:24](=[O:25])[C:23]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:22]2[C:21]1=[O:30].C(=O)([O-])[O-].[Na+].[Na+]>>[C:21]1(=[O:30])[C:22]2[C:23](=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:24](=[O:25])[NH:20]1Participants
4
Procedure
A mixture of 69.3 g of 1-[6-(trifluoromethyl) -2-pyridinyl]piperazine, and 129.6 g of N-(2-bromo-ethyl)phthalimide and 57.2 g of sodium carbonate is heated at reflux for 23 hours. The resulting precipitate is filtered off and the ethanol evaporated. The concentrate is dissolved in dichloromethane, washed with water, dried over magnesium sulfate, and evaporated. The resulting precipitate is recrystallized from isopropanol to give 39.5 g of 2-μ-[4-[6-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl]ethyl]-1H-isoindole-1,3-dione (yield 33%).