Imidazole → Ethyl 4-(1H-imidazol-1-yl)benzoate

HRID 846722

Reaction equation

HRID 846722 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.F[C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][CH:8]=1.[I-].[K+].CN(C)C(=O)C>O>[N:1]1([C:7]2[CH:17]=[CH:16][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

6

Reactant 4

HCID 795ImidazoleHCID 4875Potassium IodideHCID 31374DimethylacetamideHCID 67976Benzoic acid, 4-fluoro-, ethyl ester

Product 1

HCID 13423940Ethyl 4-(1H-imidazol-1-yl)benzoateYield 33.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 13.6 parts of 1H-imidazole, 16.8 parts of ethyl 4-fluorobenzoate, 0.1 parts of potassium iodide and 54 parts of N,N-dimethylacetamide was stirred and refluxed for 20 hours. The reaction mixture was cooled to room temperature and poured onto a lot of water. The product was extracted a few times with benzene. The combined extracts were washed thoroughly with water, dried, filtered and evaporated. The residue was stirred in hexane. The product was filtered off and dried, yielding 7.2 parts (33.3%) of ethyl 4-(1H-imidazol-1-yl)benzoate; mp. 100.3° C. (intermediate 18).

Workup

  1. temperaturerefluxed for 20 hours
  2. extractionThe product was extracted a few times with benzene
  3. washThe combined extracts were washed thoroughly with water
  4. customdried
  5. filtrationfiltered
  6. customevaporated
  7. stirringThe residue was stirred in hexane
  8. filtrationThe product was filtered off
  9. customdried

Sources & evidence

ORD record
ord-bfa5963e0e6f4035b4e62adab24026e7
Source dataset
uspto-grants-1992_08
Patent number
US05137896

Linked notes

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