Hydrochloric Acid → 1-Propanone, 3-(1H-imidazol-1-yl)-1-(2-naphthalenyl)-, monohydrochloride
Reaction equation
[ClH:1].[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([CH2:14][CH2:15][N:16]1[CH:20]=[CH:19][N:18]=[CH:17]1)=[O:13]>C1C=CC=CC=1>[ClH:1].[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([CH2:14][CH2:15][N:16]1[CH:20]=[CH:19][N:18]=[CH:17]1)=[O:13]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Ethereal hydrogen chloride is added dropwise to a solution of 1.0 g 1-[2-(2-naphthoyl)ethyl]imidazole in 100 ml anhydrous benzene until precipitation is complete. The product is filtered, washed with ether, air dried and recrystallized from methanol/acetone to yield 1-[2-(2-naphthoyl)ethyl]imidazole hydrochloride, m.p. 182.5°-186° C.