Hydrogen Bromide → 3-[(2-Aminoethyl)thiomethyl]-4-methyl-1,2,4-triazole dihydrobromide

Reaction equation

O[CH2:2][C:3]1[N:7]([CH3:8])[CH:6]=[N:5][N:4]=1.Cl.[NH2:10][CH2:11][CH2:12][SH:13].[BrH:14]>>[BrH:14].[BrH:14].[NH2:10][CH2:11][CH2:12][S:13][CH2:2][C:3]1[N:7]([CH3:8])[CH:6]=[N:5][N:4]=1

Participants

Reactant 3

HCID 260Hydrogen Bromide

HCID 9082Cysteamine Hydrochloride

HCID 15707893(4-methyl-4H-1,2,4-triazol-3-yl)methanol

Product 1

HCID 205502233-[(2-Aminoethyl)thiomethyl]-4-methyl-1,2,4-triazole dihydrobromide

Procedure

Reaction of 3-hydroxymethyl-4-methyl-1,2,4-triazole with cysteamine hydrochloride and hydrobromic acid by the procedure of Example 1 gives 3-[(2-aminoethyl)thiomethyl]-4-methyl-1,2,4-triazole dihydrobromide, m.p. 175°-177°.

Sources & evidence

ORD record: ord-95e387dfdcf5412896c4959509fad98e
Source dataset: uspto-grants-1981_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04293699

Reaction notes

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