Methanesulfonic Acid → HCID 12773948, compound

HRID 848738

Reaction equation

HRID 848738 reaction equation
[C:1]([C:3]1[CH:10]=[C:7]([CH:8]=O)[C:6]([OH:11])=[CH:5][CH:4]=1)#[N:2].[NH:12]1[C:19](=[O:20])[CH2:18][C:16](=O)[NH:15][C:13]1=[S:14].CS(O)(=O)=O>C(O)CCC>[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:11][C:16]3[NH:15][C:13](=[S:14])[NH:12][C:19](=[O:20])[C:18]=3[CH2:8][C:7]=2[CH:10]=1)#[N:2]

Participants

5

Reactant 3

HCID 6395Methanesulfonic AcidHCID 2723628Thiobarbituric acidHCID 117893503-Formyl-4-hydroxybenzonitrile

Product 1

HCID 12773948HCID 12773948, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

To n-butanol (100 ml.) add 5-cyano-salicylaldehyde (6 g.), 2-thiobarbituric acid (6 g.) and methanesulfonic acid (10 ml.) With stirring, heat the mixture to reflux for 11/2 hours. Cool, filter, and wash the solid with isopropanol and ether to yield 7-cyano-(1H,3H,5H)-(1)-benzopyrano-(2,3-d)-pyrimidine-4-one-2-thione.

Workup

  1. temperatureheat the mixture
  2. temperatureto reflux for 11/2 hours
  3. temperatureCool
  4. filtrationfilter
  5. washwash the solid with isopropanol and ether

Sources & evidence

ORD record
ord-6443daa7b40a4185803feb655054d997
Source dataset
uspto-grants-1981_10
Patent number
US04297355

Linked notes

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