Cyclopropanecarbonyl chloride → HCID 19367176, compound

Reaction equation

[CH2:1]([CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][NH:11]1)/[CH:2]=[CH:3]/[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH:16]1([C:19](Cl)=[O:20])[CH2:18][CH2:17]1>>[CH2:1]([CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][N:11]1[C:19]([CH:16]1[CH2:18][CH2:17]1)=[O:20])/[CH:2]=[CH:3]/[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 10878208HCID 10878208, compound

Product 1

HCID 19367176HCID 19367176, compound

Procedure

Stage a) The method is the same as that of Example 1.1, Stage a), the initial reactants being (E)-2-(cinnamyl)piperidine (Preparation 2A, Stage b) and cyclopropanecarboxylic acid chloride, yielding (E)-2-cinnamyl-1-cyclopropanecarbonylpiperidine (formula II; Ar=C6H5, m=1, n=2, R=cyclopropyl). Yield: 95%.

Sources & evidence

ORD record: ord-f9b9d815dd6f4e26a063c73bfdd3427e
Source dataset: uspto-grants-2000_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06013656

Reaction notes

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