Piperazine → 4-(Piperazin-1-yl)benzene-1-sulfonamide

HRID 849481

Reaction equation

HRID 849481 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>O>[N:12]1([C:2]2[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=2)[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 1202314-Fluorobenzenesulfonamide

Product 1

HCID 9018974-(Piperazin-1-yl)benzene-1-sulfonamideYield 96.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 4-fluorobenzenesulfonamide (6.95 g) and piperazine (17.1 g) in 30 mL of water is heated at 100° C. overnight. The solid is then collected, washed with water and toluene, and dried under reduced pressure to give 9.2 g of 4-(piperazin-1-yl)benzenesulfonamide; mp 219-221° C.; ms m/z 241; IR (mineral oil) 1160, 822, 1332, 608, 1593, 1137 cm-1. 1H NMR (DMSOd6) δ 2.81, 3.17, 2.3, 7.01, 7.07, 7.61.

Workup

  1. customThe solid is then collected
  2. washwashed with water and toluene
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-04797938215e4ceb83bc79bdad90df9d
Source dataset
uspto-grants-2000_01
Patent number
US06013654

Linked notes

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