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Pyridine → 2,3-Dihydro-6-Methoxy-2-(4-Methoxyphenyl)-N-Methoxy-N-Methylbenzo[b]thiophene-3-Carboxamide

HRID 850722
Notes
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Reaction equation

HRID 850722 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH:10]([C:11](O)=[O:12])[CH:9]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)[S:8][C:7]=2[CH:22]=1.C(Cl)Cl.S(Cl)(Cl)=O.[N:30]1[CH:35]=CC=CC=1.CN(C)[CH:38]=[O:39]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH:10]([C:11]([N:30]([O:39][CH3:38])[CH3:35])=[O:12])[CH:9]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)[S:8][C:7]=2[CH:22]=1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 5

HCID 1049PyridineHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 154582642,3-Dihydro-6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thiophene-3-Carboxylic Acid

Product 1

HCID 154582652,3-Dihydro-6-Methoxy-2-(4-Methoxyphenyl)-N-Methoxy-N-Methylbenzo[b]thiophene-3-Carboxamide
Yield 66.1%

Conditions

Temperature
5 °C

Procedure

To a mixture of 2,3-dihydro-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxylic acid (349.4 mg, 1.105 mmol) and methylene chloride (4 ml) is added thionyl chloride (195.7 mg, 1.645 mmol) and a catalytic amount of N, N-dimethylformamide. The contents are heated to reflux for 1 hour, then cooled and concentrated to a residue. This is then subjected to three cycles of dissolution in toluene and reconcentration, and the resulting residue taken up in methylene chloride (4 ml). To this solution is added N, O-dimethylhydroxylamine hydrochloride (118.9 mg, 1.22 mmol) and the resulting suspension cooled to 5° C. Pyridine (215 mg, 2.71 mmol) is then added via syringe. The reaction is allowed to warm to room temperature and is stirred for 16 hours. The contents are then partitioned between methylene chloride and water, and the layers separated. The organic layer is washed sequentially with 1 N hydrochloric acid, saturated aqueous sodium bicarbonate, and water, then dried over magnesium sulfate, filtered and concentrated to an oil. The oil is then chromatographed on silica gel (6:4 hexanes:ethylacetate) to afford 262.5 mg (66.1%) of title compound. IR (KBr) 2960, 2905, 1660, 1511, 1479, 1246, 1178, 1059 cm-1 ; 1H NMR (CDCl3): δ7.46 (d, 2 H, J=8.1 Hz), 6.85 (m, 3 H), 6.74 (s, 1 H), 6.57 (d, 1 H, J=8.1 Hz), 5.54 (d, 1 H, J=10.5 Hz), 4.82 (d, 1 H, J=10.5), 3.77 (s, 3 H), 3.75 (s, 3 H), 3.42 (s, 3 H), 3.23 (s, 3 H); 13C NMR (CDCl3): d 172.0, 160.2, 159.5, 143.1, 131.1, 130.2, 129.2, 124.9, 114.1, 110.9, 107.6, 61.7, 57.8, 57.3, 55.5, 55.3, 32.6. Anal. Calcd. for C19H21NO4S: C, 63.49; H, 5.89, N, 3.90; S, 8.92. Found: C, 63.48; H, 5.90; N, 3.81; S, 8.64.

Workup

  1. temperatureThe contents are heated
  2. temperatureto reflux for 1 hour
  3. temperaturecooled
  4. concentrationconcentrated to a residue
  5. dissolutionThis is then subjected to three cycles of dissolution in toluene
  6. temperatureto warm to room temperature
  7. customThe contents are then partitioned between methylene chloride and water
  8. customthe layers separated
  9. washThe organic layer is washed sequentially with 1 N hydrochloric acid, saturated aqueous sodium bicarbonate, and water
  10. dry with materialdried over magnesium sulfate
  11. filtrationfiltered
  12. concentrationconcentrated to an oil
  13. customThe oil is then chromatographed on silica gel (6:4 hexanes:ethylacetate)

Sources & evidence

ORD record
ord-ee709f635d984092ad811fd4709ca353
Source dataset
uspto-grants-2000_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06018056

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes