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Hydrochloric Acid → Ethyl hydrogen 3-[(5,5-dioxido-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazin-7-yl)oxy]phenylphosphonate

HRID 851878
Notes
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Reaction equation

HRID 851878 reaction equation
[O:1]=[S:2]1(=[O:30])[C:7]2[CH:8]=[C:9]([O:12][C:13]3[CH:14]=[C:15]([P:19](=[O:26])([O:23]CC)[O:20][CH2:21][CH3:22])[CH:16]=[CH:17][CH:18]=3)[CH:10]=[CH:11][C:6]=2[N:5]2[CH2:27][CH2:28][CH2:29][CH:4]2[NH:3]1.Cl>[OH-].[Na+]>[O:30]=[S:2]1(=[O:1])[C:7]2[CH:8]=[C:9]([O:12][C:13]3[CH:14]=[C:15]([P:19](=[O:23])([OH:26])[O:20][CH2:21][CH3:22])[CH:16]=[CH:17][CH:18]=3)[CH:10]=[CH:11][C:6]=2[N:5]2[CH2:27][CH2:28][CH2:29][CH:4]2[NH:3]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86760522Diethyl 3-[(5,5-dioxido-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazin-7-yl)oxy]phenylphosphonate

Product 1

HCID 10151118Ethyl hydrogen 3-[(5,5-dioxido-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazin-7-yl)oxy]phenylphosphonate

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

0.66 mmol of the product of Example 52 in 3 ml of 1N NaOH is stirred for 8 h at 70° C. The reaction solution is acidified with 1N HCl and the white precipitate is filtered off to yield the expected product.

Workup

  1. filtrationthe white precipitate is filtered off

Sources & evidence

ORD record
ord-3f98485dd1754453a68a78d9cea4c689
Source dataset
uspto-grants-2007_08
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07253161B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes