HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-alpha-(3-methoxyphenyl)-3-pyridinemethanol → (2-Chloro-pyridin-3-yl)-(3-methoxy-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-alpha-(3-methoxyphenyl)-3-pyridinemethanol | HCID 20145733 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (2-Chloro-pyridin-3-yl)-(3-methoxy-phenyl)-methanone | HCID 10243711 | 66% |
Reaction Steps
Combine (2-chloro-pyridin-3-yl)-(3-methoxy-phenyl)-methanol (9.40 g, 37.6 mmol), manganese (IV) oxide (30.0 g, 0.345 mol) and toluene (500 mL) and heat to reflux for one hour. Filter reaction mixture through celite, wash with toluene:dichloromethane mixture and evaporate to give the title compound (1.63 g, 66% Yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253165B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-c911483f263244228b471f1f0eb54e62 |
| Source note | uspto-grants-2007_08 |