Dimethylformamide dimethyl acetal → HCID 72466433, compound

Reaction equation

[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10]([NH2:12])=[S:11])[CH:6]=[CH:7][CH:8]=1)#[N:2].CO[CH:15](OC)[N:16]([CH3:18])[CH3:17]>>[CH3:15][N:16]([CH:18]=[N:12][C:10]([NH:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:1]#[N:2])[CH:4]=1)=[S:11])[CH3:17]

Participants

Reactant 2

HCID 78373Dimethylformamide dimethyl acetal

HCID 27579721-(3-Cyanophenyl)-2-thiourea

Product 1

HCID 72466433HCID 72466433, compoundYield 91%

Conditions

Temperature: 100 °C

Procedure

A mixture of 3 g (16.9 mmol) 1-(3-Cyanophenyl)-2-thiourea and 20 ml N,N-Dimethylformamide dimethyl acetal was heated to 100° C. for 1 h. After evaporation of the volatiles the precipitate was suspended in DCM, filtered and dried to yield 3.56 g (91%) of the title compound.

Workup

customAfter evaporation of the volatiles the precipitate
filtrationfiltered
customdried

Sources & evidence

ORD record: ord-8095ad6076e34d819f9678fc783a9013
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07253197B2

Reaction notes

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