Sodium Hydroxide → HCID 58933884, compound
Reaction equation
C([O:3][C:4](=[O:18])[C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH:11]([O:15][CH2:16][CH3:17])[O:12][CH2:13][CH3:14])[CH:6]=1)C.[OH-].[Na+]>O1CCCC1>[CH2:16]([O:15][CH:11]([O:12][CH2:13][CH3:14])[C:7]1[CH:6]=[C:5]([CH:10]=[CH:9][N:8]=1)[C:4]([OH:18])=[O:3])[CH3:17]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 2-diethoxymethyl-isonicotinic acid ethyl ester (3.0 g, 0.012 mol) in tetrahydrofuran (100 mL) was added IN sodium hydroxide (24 mL, 0.024 mol) and mixture allowed to stir for 2 h at rt. The reaction was concentrated in vacuo to give a pasty solid of 2-diethoxymethyl-isonicotinic acid, which was used in the next step as is.
Workup
- concentrationThe reaction was concentrated in vacuo
Sources & evidence
- ORD record
- ord-d5ee2e1436d445619f5b96336f3c6b68
- Source dataset
- uspto-grants-2007_08
- Patent number
- US07259157B2
Reaction notes
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