Aluminium lithium hydride → HCID 58979003, compound

HRID 854581

Reaction equation

HRID 854581 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:12]=[N:13][C:14]([Cl:17])=[CH:15][CH:16]=2)[O:8][C:9]=1[CH3:10].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[Cl:17][C:14]1[N:13]=[CH:12][C:11]([C:7]2[O:8][C:9]([CH3:10])=[C:5]([CH2:4][CH2:3][OH:2])[N:6]=2)=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 58765666[2-(6-Chloro-pyridin-3-yl)-5-methyl-oxazol-4-yl]-acetic acid methyl ester

Product 1

HCID 58979003HCID 58979003, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of [2-(6-Chloro-pyridin-3-yl)-5-methyl-oxazol-4-yl]-acetic acid methyl ester (4.0 g, 15 mmol) from step B in THF (50 mL) is added a solution of lithium aluminum hydride in THF (1.0 M, 12.5 mL, 12.5 mmol) at 0° C. After 1 hr, the reaction is quenched by water and sodium hydroxide, filtered, concentrated. The crude material is used for the next step.

Workup

  1. customthe reaction is quenched by water and sodium hydroxide
  2. filtrationfiltered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-af3bb7310b2d40ba982ffbe4852d0f55
Source dataset
uspto-grants-2007_08
Patent number
US07259175B2

Linked notes

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