HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-[4-(Imidazol-1-ylmethyl)-thiazol-2-yl]-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-[2-(4-Methoxy-phenyl)-thiazol-4-ylmethyl]-imidazole | HCID 69428685 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 4-[4-(Imidazol-1-ylmethyl)-thiazol-2-yl]-phenol | HCID 136355233 | 85.5% |
Reaction Steps
A solution of 0.54 g (2.0 mmol) 1-[2-(4-methoxy-phenyl)-thiazol-4-ylmethyl]-imidazole in 15 ml 47% aqueous hydrobromic acid was stirred at 70° C. for 4 days. The reaction mixture was poured on ice, made basic with concentrated ammonia and extracted with ethyl acetate to yield 0.44 g (85%) raw 4-[4-(imidazol-1-ylmethyl)-thiazol-2-yl]-phenol as tan crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259262B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-e53883339a67453d9791bc4ca221695e |
| Source note | uspto-grants-2007_08 |