反应详情

A solution of 0.54 g (2.0 mmol) 1-[2-(4-methoxy-phenyl)-thiazol-4-ylmethyl]-imidazole in 15 ml 47% aqueous hydrobromic acid was stirred at 70° C. for 4 days. The reaction mixture was poured on ice, made basic with concentrated ammonia and extracted with ethyl acetate to yield 0.44 g (85%) raw 4-[4-(imidazol-1-ylmethyl)-thiazol-2-yl]-phenol as tan crystals.

1. additionThe reaction mixture was poured on ice
2. extractionextracted with ethyl acetate