Aminoacetaldehyde dimethyl acetal → N-(2,2-Dimethoxyethyl)-N'-(3-iodophenyl)urea
Reaction equation
[I:1][C:2]1[CH:3]=[C:4]([N:8]=[C:9]=[O:10])[CH:5]=[CH:6][CH:7]=1.[CH3:11][O:12][CH:13]([O:16][CH3:17])[CH2:14][NH2:15]>C(Cl)Cl>[CH3:11][O:12][CH:13]([O:16][CH3:17])[CH2:14][NH:15][C:9]([NH:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([I:1])[CH:3]=1)=[O:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 20 °C
Procedure
A suspension of 3-iodophenylisocyanate (1.1 g) in DCM (10 ml) was treated with aminoacetaldehyde dimethyl acetal (0.49 ml) and stirred under nitrogen at 20° C. for 24 h. The reaction mixture was quenched by adding MeOH. The solvents were removed under reduced pressure to give the title compound (1.35 g) LCMS RT=2.92 min.
Workup
- customThe reaction mixture was quenched
- additionby adding MeOH
- customThe solvents were removed under reduced pressure
Sources & evidence
- ORD record
- ord-05b5adbcf5534c8fbac6b3df4bc730fc
- Source dataset
- uspto-grants-2006_12
- Patent number
- US07144908B2
Reaction notes
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