Diethyl Oxalate → HCID 22097060, compound

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([NH2:8])[C:5]([NH2:9])=[CH:4][C:3]=1[N:10]1[CH:14]=[CH:13][CH:12]=[CH:11]1.[C:15](OCC)(=[O:21])[C:16](OCC)=[O:17]>>[Cl:1][C:2]1[CH:7]=[C:6]2[C:5]([NH:9][C:15](=[O:21])[C:16](=[O:17])[NH:8]2)=[CH:4][C:3]=1[N:10]1[CH:14]=[CH:13][CH:12]=[CH:11]1

Participants

Reactant 2

HCID 7268Diethyl Oxalate

HCID 22097227HCID 22097227, compound

Product 1

HCID 22097060HCID 22097060, compound

Procedure

0.6 g (2.9 mmol) of N-(2-chloro-4,5-diaminophenyl)pyrrole and 32 g (221 mmol) of diethyl oxalate were refluxed for 3 hours. The reaction mixture was cooled and then the crude product was filtered off and washed with petroleum ether.

Workup

temperatureThe reaction mixture was cooled
filtrationthe crude product was filtered off
washwashed with petroleum ether

Sources & evidence

ORD record: ord-840b98d3c36f42e6b1356c01c19d7564
Source dataset: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05714489

Reaction notes

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