Methanol → HCID 19697816, compound
Reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][NH:10][C:9]2[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=2[S:7]1)=O)C.[BH4-].[Li+].CO>O1CCCC1>[OH:3][CH2:4][CH:6]1[CH2:11][NH:10][C:9]2[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=2[S:7]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
1.6 g of 2(R,S)-ethoxycarbonyl-3,4-dihydro-2H1,4-benzothiazine are reacted with 1.06 g of lithium borohydride in 20 ml of tetrahydrofuran. After addition of 10 ml of methanol, the mixture is concentrated and the residue is purified by means of FC over 80 g of silica gel (mobile phase S). This gives the title compound: Rf (S)=0.29.
Workup
- concentrationthe mixture is concentrated
- customthe residue is purified by means of FC over 80 g of silica gel (mobile phase S)
Sources & evidence
- ORD record
- ord-934ec0e0f6a147068fbacf6cdc8da363
- Source dataset
- uspto-grants-1998_02
- Patent number
- US05719141
Reaction notes
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