Hydrochloric Acid → Ceftiofur Hydrochloride

HRID 863649

Reaction equation

HRID 863649 reaction equation
[ClH:1].[CH3:2][O:3]/[N:4]=[C:5](\[C:12]([NH:14][C@@H:15]1[C:18](=[O:19])[N:17]2[C:20]([C:33]([OH:35])=[O:34])=[C:21]([CH2:24][S:25][C:26]([C:28]3[O:32][CH:31]=[CH:30][CH:29]=3)=[O:27])[CH2:22][S:23][C@H:16]12)=[O:13])/[C:6]1[N:10]=[C:9]([NH2:11])[S:8][CH:7]=1>O.CC(C)=O>[CH3:2][O:3]/[N:4]=[C:5](\[C:12]([NH:14][C@@H:15]1[C:18](=[O:19])[N:17]2[C:20]([C:33]([OH:35])=[O:34])=[C:21]([CH2:24][S:25][C:26]([C:28]3[O:32][CH:31]=[CH:30][CH:29]=3)=[O:27])[CH2:22][S:23][C@H:16]12)=[O:13])/[C:6]1[N:10]=[C:9]([NH2:11])[S:8][CH:7]=1.[ClH:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 6328657Ceftiofur

Product 1

HCID 9937686Ceftiofur Hydrochloride

Reagents, catalysts & solvents 1

HCID 18366337Propan-2-one--water (1/1)Solvent

Procedure

The preparation of crystalline ceftiofur hydrochloride is considered to involve a typical crystallization. Several methods for the preparation of ceftiofur hydrochloride are described in U.S. Pat. No. 4,902,683. In one readily used method, once the hydrochloride salt is obtained by adding hydrochloric acid to a water/acetone solution of ceftiofur, the resulting solution is cooled slowly to obtain crystalline ceftiofur hydrochloride.

Workup

  1. temperaturethe resulting solution is cooled slowly

Sources & evidence

ORD record
ord-c8c261744d074e3ca4caa76f3e176479
Source dataset
uspto-grants-1998_02
Patent number
US05721359

Linked notes

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