Poly(oxy-1,2-ethanediyl), α-(2-azidoethyl)-ω-(2-azidoethoxy)- → Bis-Aminoethylglycol

The diazide (17) (3.55 g, 17.85 mmol) in THF (10mL) was added dropwise into a cold (-5° C.) stirred mixture of lithium aluminum hydride (1.83 g, 48.2 mmol) in THF (20 mL). The reaction mixture was kept at -5° C. and carefully quenched with water (10 mL). The THF layer was filtered to remove the inorganic salts, dried over Na2SO4, and evaporated in vacuo to afford the diamine (18) (2.56 g, 97% yield).

1. customwas kept at -5° C.
2. customcarefully quenched with water (10 mL)
3. filtrationThe THF layer was filtered
4. customto remove the inorganic salts
5. dry with materialdried over Na2SO4
6. customevaporated in vacuo

ORD record

ord-7b18f818422b45a7b79aa84b48553855

Source dataset

uspto-grants-1996_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05561042