Sodium Hydroxide → Leucinamide

HRID 864277

Reaction equation

HRID 864277 reaction equation
[NH2:1][C@H:2]([C:7]([NH2:9])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].Cl.[OH-].[Na+]>CC(N(C)C)=O.O>[NH2:1][C@H:2]([C:7]([NH2:9])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 2733199Leucinamide hydrochloride

Product 1

HCID 69640Leucinamide

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 31374DimethylacetamideSolvent2×

Procedure

1.25M solution of Leu-NH2 in DMAC was prepared by dissolving Leu-NH2.HCl (1.33 g, 7.98 mmol) in 5.0 mL of water, titrating to pH 8.0 with 1M NaOH, lyophilizing, and taking up the residue in 6.4 ml of DMAC. The NaCl precipitate was removed by filtering through a fine glass frit to give a clear solution of pH 9.25.

Workup

  1. customThe NaCl precipitate was removed
  2. filtrationby filtering through a fine glass frit
  3. customto give a clear solution of pH 9.25

Sources & evidence

ORD record
ord-b5d127ef1e6044608b68a102b37d5fbf
Source dataset
uspto-grants-1996_10
Patent number
US05563044

Linked notes

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