Chloroform → Gentamicin

HRID 865827

Reaction equation

HRID 865827 reaction equation
C(Cl)(Cl)Cl.CO.O.C(O)(=O)/C=C/CCCCCCCCC(O)=O.C(Cl)(Cl)Cl.C1C=C2C(C(O)(O)C(=O)C2=CC=1)=O.C[C@@H](N)[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3OC[C@@](O)(C)[C@H](NC)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)CC1.[CH3:73][C@@H:74]([NH:104][CH3:105])[C@H:75]1[O:80][C@H:79]([O:81][C@H:82]2[C@H:87]([OH:88])[C@@H:86]([O:89][C@H:90]3[O:95][CH2:94][C@@:93]([OH:97])([CH3:96])[C@H:92]([NH:98][CH3:99])[C@H:91]3[OH:100])[C@H:85]([NH2:101])[CH2:84][C@@H:83]2[NH2:102])[C@H:78]([NH2:103])[CH2:77][CH2:76]1.C[C@@]1(O)[C@H](NC)[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H](N)C[C@H]2N)OC1.OS(O)(=O)=O>CO>[CH3:73][CH:74]([NH:104][CH3:105])[CH:75]1[O:80][CH:79]([O:81][CH:82]2[CH:87]([OH:88])[CH:86]([O:89][CH:90]3[O:95][CH2:94][C:93]([OH:97])([CH3:96])[CH:92]([NH:98][CH3:99])[CH:91]3[OH:100])[CH:85]([NH2:101])[CH2:84][CH:83]2[NH2:102])[CH:78]([NH2:103])[CH2:77][CH2:76]1

Participants

7

Reactant 5

HCID 6212ChloroformHCID 10236NinhydrinHCID 5283028Traumatic AcidHCID 6419933Gentamicine sulfateHCID 21866399Chloroform methanol water

Product 1

HCID 3467Gentamicin

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

TLC: eluent chloroform/methanol/water/28% NH3 50:40:7:3; RF=0.67 (traumatic acid): eluent chloroform,/methanol/28% NH3 1:1:1 ninhydrin as indicator: three stains are observed like in gentamycin sulfate used as standard sample.

Sources & evidence

ORD record
ord-45b93185a8c045fd85fdb2e31701cbfa
Source dataset
uspto-grants-1996_10
Patent number
US05567716

Linked notes

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