Methylamine → N-benzhydryl-N'-methylthiourea

HRID 866861

Reaction equation

HRID 866861 reaction equation
[CH:1]([N:14]=[C:15]=[S:16])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17][NH2:18]>CCOCC>[CH:1]([NH:14][C:15]([NH:18][CH3:17])=[S:16])([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 520742Benzhydryl isothiocyanate

Product 1

HCID 3442043N-benzhydryl-N'-methylthiourea

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 13.50 g (0.06 Mole) of benzhydrylisothiocyanate in ether is saturated with anhydrous methylamine in an ice bath. The crystals are filtered to yield the product, N-benzhydryl-N'-methylthiourea; mp 152°-154° C, which is sufficiently pure for the next step.

Workup

  1. filtrationThe crystals are filtered

Sources & evidence

ORD record
ord-7d89f92d550b4f6b82ec1dea8e722a52
Source dataset
uspto-grants-1978_07
Patent number
US04101659

Linked notes

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