Hydrochloric Acid → 5-Acetoxy-2-(1-carbamoyl-1,2-dimethylpropyl-carbamoyl)-6-methyl-nicotinic acid methyl ester

HRID 867832

Reaction equation

HRID 867832 reaction equation
Cl.[C:2]([O:5][C:6]1[C:7]([CH3:26])=[N:8][C:9]([C:15](=[O:25])[NH:16][C:17]([C:22](=[O:24])[NH2:23])([CH3:21])[CH:18]([CH3:20])[CH3:19])=[C:10]([CH:14]=1)[C:11]([OH:13])=[O:12])(=[O:4])[CH3:3].[CH3:27]O>>[CH3:27][O:12][C:11](=[O:13])[C:10]1[CH:14]=[C:6]([O:5][C:2](=[O:4])[CH3:3])[C:7]([CH3:26])=[N:8][C:9]=1[C:15](=[O:25])[NH:16][C:17]([C:22](=[O:24])[NH2:23])([CH3:21])[CH:18]([CH3:19])[CH3:20]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 137994455-Acetoxy-2-(1-carbamoyl-1,2-dimethylpropyl-carbamoyl)-6-methyl-nicotinic acid

Product 1

HCID 137994465-Acetoxy-2-(1-carbamoyl-1,2-dimethylpropyl-carbamoyl)-6-methyl-nicotinic acid methyl ester

Procedure

Hydrochloric acid gas is led for 3 hours through a solution of 53 g (0.151 mol) 5-acetoxy-2-(1-carbamoyl-1,2-dimethylpropyl-carbamoyl)-6-methyl-nicotinic acid in 500 ml absolute methanol boiling under reflux. Then, the solvent is evaporated and the product is dried in a vacuum.

Workup

  1. temperatureunder reflux
  2. customThen, the solvent is evaporated
  3. customthe product is dried in a vacuum

Sources & evidence

ORD record
ord-e62c2d8550e34b53a0020181c40a7b03
Source dataset
uspto-grants-1988_10
Patent number
US04776876

Linked notes

Loading…