Malonic Acid → 2-Propenoic acid, 3-(5-fluoro-3-pyridinyl)-
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=O)[CH:5]=[N:6][CH:7]=1.C(O)(=O)[CH2:11][C:12]([OH:14])=[O:13].N1CCCCC1>N1C=CC=CC=1>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:11][C:12]([OH:14])=[O:13])[CH:5]=[N:6][CH:7]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 110 °C
Procedure
A mixture of 1.1 g of the crude 5-fluoro-3-pyridinecarbaldehyde, 1.8 g of malonic acid, 0.15 ml of piperidine, and 7 ml of pyridine is stirred at 110° C. for 2 hours. The reaction mixture is concentrated, and 20 ml of water is added. The resulting precipitate is collected and washed with cold water to give 0.5 g of the title compound.
Workup
- concentrationThe reaction mixture is concentrated
- addition20 ml of water is added
- customThe resulting precipitate is collected
- washwashed with cold water
Sources & evidence
- ORD record
- ord-398c328f6d974241a82489a18330cfbb
- Source dataset
- uspto-grants-1988_10
- Patent number
- US04778796
Reaction notes
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