Cyclopentylamine → N-cyclopentyl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine

HRID 868516

Reaction equation

HRID 868516 reaction equation
Cl[C:2]1[C:3]2[N:4]([C:12]([CH3:15])=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH:16]1([NH2:21])[CH2:20][CH2:19][CH2:18][CH2:17]1>CN(C=O)C>[CH:16]1([NH:21][C:2]2[C:3]3[N:4]([C:12]([CH3:15])=[N:13][N:14]=3)[C:5]3[C:10]([N:11]=2)=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 2906CyclopentylamineHCID 27686434-Chloro-1-methyl[1,2,4]triazolo[4,3-a]quinoxaline

Product 1

HCID 899185N-cyclopentyl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amineYield 84.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A reaction mixture of 4-chloro-1-methyl[1,2,4]triazolo[4,3-a]quinoxaline (1.0 g; 0.004 mole) and cyclopentanamine (1.17 g; 0.013 mole) in 15 ml of DMF was stirred at room temperature for 20 hours. The reaction mixture was poured over ice-water and the precipitated solid was filtered, washed with water and dried affording 0.9 g (74%) of N-cyclopentyl-1methyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine having a mp of 196°-198° C.

Workup

  1. filtrationthe precipitated solid was filtered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-3c9dd309aede4145b6b54e49878bd7e4
Source dataset
uspto-grants-1988_10
Patent number
US04780464

Linked notes

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