2-Bromopropane → 2-Iodo-8-isopropoxyquinoline

Reaction equation

[I:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([OH:12])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.Br[CH:14]([CH3:16])[CH3:15]>>[I:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([O:12][CH:14]([CH3:16])[CH3:15])[CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

Reactant 2

HCID 63582-Bromopropane

HCID 211635362-Iodoquinolin-8-ol

Product 1

HCID 579393102-Iodo-8-isopropoxyquinolineYield 84%

Procedure

Reaction of 2-iodo-quinolin-8-ol 8 with 2-bromopropane following the method described in Example 8 gave 2-iodo-8-isopropoxyquinoline 9 in 84% yield. 9:

Sources & evidence

ORD record: ord-38723f1465dd450cbde137c14d46f1a2
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08975278B2

Reaction notes

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