Hydrochloric Acid → (1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine hydrochloride

HRID 875153

Reaction equation

HRID 875153 reaction equation
C(OC([NH:8][C@@:9]([CH3:24])([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:10]([N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)=[O:11])=O)(C)(C)C.[ClH:25]>O1CCOCC1>[ClH:25].[CH3:24][C@:9]([NH2:8])([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:10]([N:12]1[CH2:13][CH2:14][O:15][CH2:16][CH2:17]1)=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57444165tert-butoxycarbonyl-(1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine

Product 1

HCID 57444166(1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 630 mg (1.884 mmol) of N-(tert-butoxycarbonyl)-(1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine in 20 mL of dioxane was treated with 2.5 mL of HCl 4N in dioxane overnight. The solvent was removed under vacuo and the solid was triturated with diethylether yielding 560 mg of the title compound.

Workup

  1. customThe solvent was removed under vacuo
  2. customthe solid was triturated with diethylether yielding 560 mg of the title compound

Sources & evidence

ORD record
ord-40e08d9d40fc444d99428ac378a1c5c8
Source dataset
uspto-grants-2015_03
Patent number
US08981089B2

Linked notes

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