Diethyl Ether → HCID 90413778, compound
Reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](O)=[O:10])=[CH:4][C:3]=1[Br:12].C[Si]([CH:17]=[N+:18]=[N-])(C)C.C(OCC)C>CO.ClCCl>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:18][CH3:17])=[O:10])=[CH:4][C:3]=1[Br:12]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
To 2-(4-amino-3-bromo-phenyl)acetic acid (5 g, 21.73 mmol) in methanol (50 mL) and dichlormethane (100 mL) is added at −5° C. trimethylsilyldiazomethane in diethylether 2 mol/L (31.51 mL, 63.03 mmol) dropwise over a period of 30 min. The reaction mixture is allowed to warm up to r.t. and concentrated. The crude product is used without further purification.
Workup
- concentrationconcentrated
- customThe crude product is used without further purification
Sources & evidence
- ORD record
- ord-79de351fc1e9405fb5426db625d9bd33
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08987249B2
Reaction notes
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