C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1.O1[C:22]2([CH2:27][CH2:26][N:25]([C:28]([N:30]3[CH2:35][CH:34]([C:36]4[CH:41]=[CH:40][C:39]([C:42]([F:45])([F:44])[F:43])=[CH:38][CH:37]=4)[CH2:33][CH:32]([NH:46][C:47]([CH:49]4[CH2:53][CH2:52][CH2:51][CH2:50]4)=[O:48])[CH2:31]3)=[O:29])[CH2:24][CH2:23]2)[O:21]CC1>CC(C)=O.O>[O:21]=[C:22]1[CH2:27][CH2:26][N:25]([C:28]([N:30]2[CH2:35][CH:34]([C:36]3[CH:41]=[CH:40][C:39]([C:42]([F:45])([F:43])[F:44])=[CH:38][CH:37]=3)[CH2:33][CH:32]([NH:46][C:47]([CH:49]3[CH2:53][CH2:52][CH2:51][CH2:50]3)=[O:48])[CH2:31]2)=[O:29])[CH2:24][CH2:23]114.3 mg of pyridinium p-toluenesulphonate (0.057 mmol) were added to a solution of the acetal from Example 63A (97.2 mg, 0.191 mmol) in 5.5 ml of acetone/water (10:1), and the mixture was stirred under reflux overnight. Another 14.3 mg of pyridinium p-toluenesulphonate (0.057 mmol) were added, and the mixture was stirred under reflux for another night. The mixture was then cooled, and the precipitate formed was filtered off. Yield: 66.2 mg (74% of theory)
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