4-Pyrrolidinopyridine → 4-Hydrazino-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyrimidine

HRID 876670

Reaction equation

HRID 876670 reaction equation
Cl[C:2]1[CH:7]=[C:6]([NH:8][NH2:9])[N:5]=[CH:4][N:3]=1.[N:10]1([C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)[CH2:14][CH2:13][CH2:12][CH2:11]1>O>[NH:8]([C:6]1[CH:7]=[C:2]([N:18]2[CH2:19][CH2:20][CH:15]([N:10]3[CH2:14][CH2:13][CH2:12][CH2:11]3)[CH2:16][CH2:17]2)[N:3]=[CH:4][N:5]=1)[NH2:9]

Participants

4

Reactant 2

HCID 755674-PyrrolidinopyridineHCID 2472224-Chloro-6-hydrazinylpyrimidine

Product 1

HCID 596037004-Hydrazino-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyrimidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2.0 g (13.8 mmol) of the compound from Example 7A and 4.3 g (27.7 mmol) 4-pyrrolidin-1-ylpyridine is stirred in 20 ml water at 100° C. for 16 h. The solid which has precipitated out is filtered off, washed first with ethanol and then with diethyl ether and dried in vacuo.

Workup

  1. customThe solid which has precipitated out
  2. filtrationis filtered off
  3. washwashed first with ethanol
  4. dry with materialwith diethyl ether and dried in vacuo

Sources & evidence

ORD record
ord-357e77f54b864dfeaabd35a9be5c9671
Source dataset
uspto-grants-2015_03
Patent number
US08987261B2

Linked notes

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