2-Methoxyethylamine → (6-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(2-methoxy-ethyl)-amine

HRID 876929

Reaction equation

[CH3:1][O:2][CH2:3][CH2:4][NH2:5].Cl[C:7]1[N:12]=[C:11]([Cl:13])[N:10]=[C:9]2[N:14]([CH3:17])[N:15]=[CH:16][C:8]=12>>[Cl:13][C:11]1[N:10]=[C:9]2[N:14]([CH3:17])[N:15]=[CH:16][C:8]2=[C:7]([NH:5][CH2:4][CH2:3][O:2][CH3:1])[N:12]=1

Participants

Reactant 2

HCID 80182-Methoxyethylamine

HCID 2222474,6-dichloro-1-methyl-1H-pyrazolo(3,4-d)pyrimidine

Product 1

HCID 58345940(6-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(2-methoxy-ethyl)-amine

Procedure

Reaction of 2-methoxyethylamine with 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine 5 by General Procedure B gave (6-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-(2-methoxy-ethyl)-amine.

Sources & evidence

ORD record: ord-81abfe90672847fd828afad5a2fe09c7
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08987280B2

Linked notes

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