Hydrochloric Acid → 4-Methyl-1,4lambda5-azaphosphinan-4-one hydrochloride

HRID 877075

Reaction equation

HRID 877075 reaction equation
C([N:8]1[CH2:13][CH2:12][P:11](=[O:15])([CH3:14])[CH2:10][CH2:9]1)C1C=CC=CC=1.[ClH:16]>CO.[Pd]>[ClH:16].[CH3:14][P:11]1(=[O:15])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 668332461-Benzyl-4-methyl-1,4-azaphosphinane 4-oxide

Product 1

HCID 668330534-Methyl-1,4lambda5-azaphosphinan-4-one hydrochloride

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 1-benzyl-4-methyl-1,4-azaphosphinane 4-oxide (5 g) in methanol (50 mL) and 3 M HCl (10 mL) with palladium on carbon (10%, 1.0 g) was hydrogenated on a Parr shaker for 24 hours at 60 psi. The mixture was filtered through Celite and all solvents were removed under reduced pressure to give a white crystalline solid, which was used without further purification.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. customall solvents were removed under reduced pressure
  3. customto give a white crystalline solid, which
  4. customwas used without further purification

Sources & evidence

ORD record
ord-c4ab8ba9378345c89957f08e06cc1dc3
Source dataset
uspto-grants-2015_03
Patent number
US08987284B2

Linked notes

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