Oxalyl chloride → Dimethyl-1,3-oxazole-5-carbonyl chloride

HRID 879892

Reaction equation

HRID 879892 reaction equation
[CH3:1][C:2]1[O:3][C:4]([C:8]([OH:10])=O)=[C:5]([CH3:7])[N:6]=1.C(Cl)(=O)C([Cl:14])=O>C(Cl)Cl>[CH3:1][C:2]1[O:3][C:4]([C:8]([Cl:14])=[O:10])=[C:5]([CH3:7])[N:6]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 1132979Dimethyl-1,3-oxazole-5-carboxylic acid

Product 1

HCID 12336332Dimethyl-1,3-oxazole-5-carbonyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirring solution of 2,4-dimethyl-oxazole-5-carboxylic acid (30 mg) in DCM (2.0 mL), oxalyl chloride (3.0 eq) was added at room temperature. The reaction mixture was stirred for 30 minutes. Solvents were evaporated and dried under vaccuo to afford 2,4-dimethyl-oxazole-5-carbonyl chloride.

Workup

  1. customSolvents were evaporated
  2. customdried under vaccuo

Sources & evidence

ORD record
ord-a278cc7d859c47cfa5722c2190158b6e
Source dataset
uspto-grants-2015_03
Patent number
US08987295B2

Linked notes

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