Oxalyl chloride → 1192719-19-9
Reaction equation
[C:1](Cl)(=[O:5])[C:2]([Cl:4])=[O:3].[CH3:7][N:8]1[CH:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:10]=[C:9]1[CH3:19]>ClCCl>[CH3:7][N:8]1[C:9]([CH3:19])=[CH:10][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:12]1[C:1](=[O:5])[C:2]([Cl:4])=[O:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Oxalyl chloride (19.5 mL, 0.21 mol) was added slowly to a 0° C. solution of 1,2-dimethyl-4-phenyl-pyrrole (30.5 g, 0.178 mol) in dry dichloromethane (150 mL). The reaction mixture was warmed to room temperature and stirred for 1 h. The solvent was removed in vacuo to afford 2-(1,5-dimethyl-3-phenyl-pyrrol-2-yl)-2-oxo-acetyl chloride (46 g, 99%) as a brown oil.
Workup
- customThe solvent was removed in vacuo
Sources & evidence
- ORD record
- ord-45c7955e852e41dda2de3c9d2b86b053
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08993574B2
Reaction notes
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