Methylamine → 1-Isobutyl-3-methylthiourea

HRID 883552

Reaction equation

HRID 883552 reaction equation
[CH3:1][NH2:2].[CH2:3]([N:7]=[C:8]=[S:9])[CH:4]([CH3:6])[CH3:5]>>[CH2:3]([NH:7][C:8]([NH:2][CH3:1])=[S:9])[CH:4]([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 68960Isobutyl isothiocyanate

Product 1

HCID 155682431-Isobutyl-3-methylthioureaYield 98.2%

Procedure

Methylamine (2M in methanol, 20.0 mL, 40.2 mmol) was added dropwise to isobutylisothiocyanate (2.00 mL, 16.5 mmol) during 15 minutes at room temperature. The reaction mixture was heated to reflux for 3.5 h and the solvent was evaporated off to give the title compound (2.37 g, 98%) as a colourless oil.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 3.5 h
  3. customthe solvent was evaporated off

Sources & evidence

ORD record
ord-a009c415bc374a209f29a2f4261b069c
Source dataset
uspto-grants-2012_08
Patent number
US08236951B2

Linked notes

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